Computational techniques have become indispensable tools in solving complex problems in transport phenomena. This book, first published in 1997, provides a clear, user-oriented introduction to the subject. Each self-contained chapter includes a detailed worked example and a discussion of the problem system equations. Also included are the numerical methods used; computer code for the solution of the problem system equations; discussion of the numerical solution with emphasis on physical interpretation; and when appropriate, a comparison of the numerical solution with an analytical solution or a discussion of how the numerical solution goes beyond what can be done analytically, especially for nonlinear problems. Intended for students and a broad range of scientists and engineers, the book includes computer code written in transportable Fortran so that readers can produce the numerical solutions and then extend them to other cases. The programs are also available on the author's web site at http://www.lehigh.edu/~wes1/wes1.html.

Computational Mathematics in Engineering and Applied Science provides numerical algorithms and associated software for solving a spectrum of problems in ordinary differential equations (ODEs), differential algebraic equations (DAEs), and partial differential equations (PDEs) that occur in science and engineering. It presents detailed examples, each including a complete analysis of a computer code written in transportable Fortran 77. Each example also includes a discussion of the problem equations, the coding of the equations, and the computed numerical solution. The benefits of using quality general-purpose library routines to solve ODE/DAE/PDE problems are illustrated as well.

This popular, classic book is a valuable reference for methodologies in numerical mathematics applicable to a broad spectrum of problems encountered across many disciplines- virtually all fields of science and engineering. It also serves as an excellent text for senior undergraduates or beginning graduate students in computational science.

Scientists and engineers attempting to solve complex problems require efficient, effective ways of applying numerical methods to ODEs and PDEs. They need a resource that enables fast access to library routines in their choice of a programming language.

Ordinary and Partial Differential Equation Routines in C, C++, Fortran, Java, Maple, and MATLAB provides a set of ODE/PDE integration routines in the six most widely used languages in science and engineering, enabling scientists and engineers to apply ODE/PDE analysis toward solving complex problems.

This text concisely reviews integration algorithms, then analyzes the widely used Runge Kutta method ( since hyphenation is used here, I added it below; hyphenation could also be dropped since it is not used in the book). It first presents a complete code before discussing its components in detail, focusing on integration concepts such as error monitoring and control.

The format allows you to understand the basics of ODE/PDE integration, then calculate sample numerical solutions within your targeted programming language. The applications discussed can be used as templates for the development of a spectrum of new applications and associated codes.

Features a solid foundation of mathematical and computational tools to formulate and solve real-world PDE problems across various fields With a step-by-step approach to solving partial differential equations (PDEs), Differential Equation Analysis in Biomedical Science and Engineering: Partial Differential Equation Applications with R successfully applies computational techniques for solving real-world PDE problems that are found in a variety of fields, including chemistry, physics, biology, and physiology. The book provides readers with the necessary knowledge to reproduce and extend the computed numerical solutions and is a valuable resource for dealing with a broad class of linear and nonlinear partial differential equations. The author s primary focus is on models expressed as systems of PDEs, which generally result from including spatial effects so that the PDE dependent variables are functions of both space and time, unlike ordinary differential equation (ODE) systems that pertain to time only. As such, the book emphasizes details of the numerical algorithms and how the solutions were computed. Featuring computer-based mathematical models for solving real-world problems in the biological and biomedical sciences and engineering, the book also includes: * R routines to facilitate the immediate use of computation for solving differential equation problems without having to first learn the basic concepts of numerical analysis and programming for PDEs * Models as systems of PDEs and associated initial and boundary conditions with explanations of the associated chemistry, physics, biology, and physiology * Numerical solutions of the presented model equations with a discussion of the important features of the solutions * Aspects of general PDE computation through various biomedical science and engineering applications Differential Equation Analysis in Biomedical Science and Engineering: Partial Differential Equation Applications with R is an excellent reference for researchers, scientists, clinicians, medical researchers, engineers, statisticians, epidemiologists, and pharmacokineticists who are interested in both clinical applications and interpretation of experimental data with mathematical models in order to efficiently solve the associated differential equations. The book is also useful as a textbook for graduate-level courses in mathematics, biomedical science and engineering, biology, biophysics, biochemistry, medicine, and engineering.

Time delayed (lagged) variables are an inherent feature of biological/physiological systems. For example, infection from a disease may at first be asymptomatic, and only after a delay is the infection apparent so that treatment can begin.Thus, to adequately describe physiological systems, time delays are frequently required and must be included in the equations of mathematical models. The intent of this book is to present a methodology for the formulation and computer implementation of mathematical models based on time delay ordinary differential equations (DODEs) and partial differential equations (DPDEs). The DODE/DPDE methodology is presented through a series of example applications, particularly in biomedical science and engineering (BMSE). The computer-based implementation of the example models is explained with routines coded (programmed) in R, a quality, open-source scientific computing system that is readily available from the Internet. Formal mathematics is minimized, e.g., no theorems and proofs. Rather, the presentation is through detailed examples that the reader/researcher/analyst can execute on modest computers. The DPDE analysis is based on the method of lines (MOL), an established general algorithm for PDEs, implemented with finite differences. The example applications can first be executed to confirm the reported solutions, then extended by variation of the parameters and the equation terms, and even the forumulation and use of alternative DODE/DPDE models. * Introduces time delay ordinary and partial differential equations (DODE/DPDEs) and their numerical computer-based integration (solution) * Illustrates the computer implementation of DODE/DPDE models with coding (programming) in R, a quality, open-source scientific programming system readily available from the Internet * Applies DODE/DPDE models to biological/physiological systems through a series of examples * Provides the R routines for all of the illustrative applications through a download link * Facilitates the use of the models with reasonable time and effort on modest computers

Computational techniques have become indispensable tools in solving complex problems in transport phenomena. This book provides a clear, user-oriented introduction to the subject of computational transport phenomena. Each self-contained chapter includes a detailed worked example and a discussion of the problem system equations. Also included are the numerical methods used; computer code for the solution of the problem system equations; discussion of the numerical solution with emphasis on physical interpretation; and, when appropriate, a comparison of the numerical solution with an analytical solution or a discussion of how the numerical solution goes beyond what can be done analytically, especially for nonlinear problems. Intended for students and a broad range of scientists and engineers, the book includes computer code written in transportable Fortran so the reader can produce the numerical solutions and then extend them to other cases.

Included in this set: Differential Equation Analysis in Biomedical Science and Engineering: Partial Differential Equation Applications with R With the needed mathematical and computational tools, this book provides a solid foundation in formulating and solving real-world PDE problems in various fields from applied mathematics, engineering, and computer science to biology and medicine, includes supporting documentation and step-by-step guidance, and features R codes that can be easily and conveniently used by readers. Topical coverage includes: introduction to PDEs and chemotaxis; pattern formation; Belousov-Zhabotinskii reaction system; Hodgkin-Huxley and Fitzhugh-Nagumo models; spatiotemporal effects of anesthesia during surgery; developing retinal vasculature; temperature distributions in cryosurgery; multisection membrane separation system; and origin of PDE reaction-diffusion equations. Differential Equation Analysis in Biomedical Science and Engineering: Ordinary Differential Equation Applications with R This book provides readers with the necessary knowledge to reproduce and extend the numerical solutions with reasonable effort and is a valuable resource dealing with a broad class of differential and nonlinear algebraic equations. The investigated problems include ODEs and associated initial conditions. The studied equations describe a wide variety of basic phenomena such as apoptosis, stem cell differentiation, and many others. Topical coverage includes: introduction to ODE analysis and bioreactor dynamics; diabetes glucose tolerance test; apoptosis; dynamic neuron model; stem cell differentiation; acetylcholine neurocycle; tuberculosis with differential infectivity; corneal curvature; and stiff ODE integration.

Presents the methodology and applications of ODE and PDE models within biomedical science and engineering With an emphasis on the method of lines (MOL) for partial differential equation (PDE) numerical integration, Method of Lines PDE Analysis in Biomedical Science and Engineering demonstrates the use of numerical methods for the computer solution of PDEs as applied to biomedical science and engineering (BMSE). Written by a well-known researcher in the field, the book provides an introduction to basic numerical methods for initial/boundary value PDEs before moving on to specific BMSE applications of PDEs. Featuring a straightforward approach, the book s chapters follow a consistent and comprehensive format. First, each chapter begins by presenting the model as an ordinary differential equation (ODE)/PDE system, including the initial and boundary conditions. Next, the programming of the model equations is introduced through a series of R routines that primarily implement MOL for PDEs. Subsequently, the resulting numerical and graphical solution is discussed and interpreted with respect to the model equations. Finally, each chapter concludes with a review of the numerical algorithm performance, general observations and results, and possible extensions of the model. Method of Lines PDE Analysis in Biomedical Science and Engineering also includes: * Examples of MOL analysis of PDEs, including BMSE applications in wave front resolution in chromatography, VEGF angiogenesis, thermographic tumor location, blood-tissue transport, two fluid and membrane mass transfer, artificial liver support system, cross diffusion epidemiology, oncolytic virotherapy, tumor cell density in glioblastomas, and variable grids * Discussions on the use of R software, which facilitates immediate solutions to differential equation problems without having to first learn the basic concepts of numerical analysis for PDEs and the programming of PDE algorithms * A companion website that provides source code for the R routines Method of Lines PDE Analysis in Biomedical Science and Engineering is an introductory reference for researchers, scientists, clinicians, medical researchers, mathematicians, statisticians, chemical engineers, epidemiologists, and pharmacokineticists as well as anyone interested in clinical applications and the interpretation of experimental data with differential equation models. The book is also an ideal textbook for graduate-level courses in applied mathematics, BMSE, biology, biophysics, biochemistry, medicine, and engineering.